Sequence comparison by sequence harmony identifies subtype-specific functional sites
نویسندگان
چکیده
منابع مشابه
Sequence comparison by sequence harmony identifies subtype-specific functional sites
Multiple sequence alignments are often used to reveal functionally important residues within a protein family. They can be particularly useful for the identification of key residues that determine functional differences between protein subfamilies. We present a new entropy-based method, Sequence Harmony (SH) that accurately detects subfamily-specific positions from a multiple sequence alignment...
متن کاملSequence Comparison by Sequence Harmony Identifies Sub-type Specific Sites
Multiple sequence alignments are often used to reveal functionally important residues within a protein family. They can be particularly useful for the identification of key residues that determine functional differences between protein subfamilies. We present a new entropybased method, Sequence Harmony (SH) that accurately detects subfamily specific positions from a multiple sequence alignment....
متن کاملSub-type Specific Sites for SMAD Receptor Binding Identified by Sequence Comparison Using “Sequence Harmony”
c © 2006 by John von Neumann Institute for Computing Permission to make digital or hard copies of portions of this work for personal or classroom use is granted provided that the copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. To copy otherwise requires prior specific permission by the publisher ment...
متن کاملSequence harmony: detecting functional specificity from alignments
Multiple sequence alignments are often used for the identification of key specificity-determining residues within protein families. We present a web server implementation of the Sequence Harmony (SH) method previously introduced. SH accurately detects subfamily specific positions from a multiple alignment by scoring compositional differences between subfamilies, without imposing conservation. T...
متن کاملMulti-Harmony: detecting functional specificity from sequence alignment
Many protein families contain sub-families with functional specialization, such as binding different ligands or being involved in different protein-protein interactions. A small number of amino acids generally determine functional specificity. The identification of these residues can aid the understanding of protein function and help finding targets for experimental analysis. Here, we present m...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2006
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/gkl901